Warning: Spoilers Below. Do not read, unless you're cool with knowing what happens in Family History: Part 2.
I guess this isn't even that good of a song, but at the time, it seemed like the perfect background song to play when Calvin and Henry Austin get the hell out of dodge (Northgate).
Muse - "Guiding Light" - for when poor Henry Austin dies, and Calvin is left to deal with the grief. I suppose he was Calvin's "Guiding Light", or at the very least, his best friend.
Muse - "Knights of Cydonia" - for when Calvin takes Collie by the hand and they explore the world. The lyrics are actually kind of perfect, too - "Come ride with me/through the veins of history," and then later, "Don't waste your time or time will waste you." Squeee. That is too perfect for words.